9-hydroxy-4-androstene-3,17-dione,(:https://www.bloomtechz.com/synthetic-chemical/api-researching-only/9-hydroxy-4-androstene-3-17-dione-cas-560-62.html) also known as 4-OHA, has a molecular formula of C19H26O3 and a molecular weight of 302.41 g/mol. It is an androsterone inducer, a naturally occurring steroid substance. Appearance is white to light yellow powder, in the form of crystals or crystals. It is easily soluble in organic solvents such as ethanol, acetone, chloroform, ether and benzene, but insoluble in water. There are two main absorption peaks in the ultraviolet region, one at 227 nm and the other at 274 nm. The infrared spectrum has relatively obvious absorption peaks, mainly including the vibration of OH bond (3440 cm^-1), the vibration of ketone group (1732 cm^-1), and the vibration of propane group and aromatic hydrocarbon group, etc. Nuclear magnetic resonance spectra include carbon-13 NMR and hydrogen-1 NMR. In Hydrogen-1 NMR, it has a double-bonded benzene ring moiety, and due to its position, 10 different peaks appear, while in Carbon-13 NMR, 6 peaks appear. It can be converted into androgens or estrogens in the body, and has effects on the reproductive system and metabolism. It has broad application prospects and research value. The researchers of Shaanxi Chuzhan Chemical are exploring its molecular structure, biological activity and pharmacological mechanism, and are expected to develop more safe and effective drugs and health products to serve human health and quality of life.
1. Androgen:
9-hydroxy-4-androstene-3,17-dione is an important androgen precursor. It is converted into testosterone, dihydrotestosterone and other male hormones through the catalytic action of multiple enzymes. These hormones have important physiological roles in both men and women, including maintaining normal reproduction and sexual characteristics, promoting muscle growth and bone density, regulating lipid metabolism, etc.
2. Physical Enhancer:
Due to its bioactivity similar to testosterone, 9-hydroxy-4-androstene-3,17-dione is widely used by athletes and bodybuilders as a performance enhancer. Several studies have shown that supplementation with 9-hydroxy-4-androstene-3,17-dione can improve muscle strength, endurance and body weight, and promote muscle growth. However, this use is currently limited by dosage and control to avoid adverse health effects.
3. Dehydrogenase inhibitors:
9-hydroxy-4-androstene-3,17-dione is a potent dehydrogenase inhibitor. Dehydrogenases are an important family of enzymes involved in a variety of metabolic and reaction processes. Inhibition of dehydrogenase activity can block hormone synthesis and metabolic pathways, resulting in multiple pharmacological effects. For example, inhibiting estrogen metabolism can reduce the incidence of female diseases such as breast cancer and endometrial cancer; inhibiting testosterone metabolism can treat testosterone deficiency and related male reproductive problems.
4. Antiestrogens:
9-hydroxy-4-androstene-3,17-dione can be used as an anti-estrogen in cancer therapy. Estrogen is one of the important causes of many cancers, including breast cancer, ovarian cancer, endometrial cancer and so on. By inhibiting the synthesis and metabolism of estrogen, its effect at the cellular level can be reduced, thereby controlling the development of cancer. 9-hydroxy-4-androstene-3,17-dione has been shown to have good anti-estrogen activity and has been used to treat various types of estrogen-dependent cancers.
5. Reproductive health supplements:
9-hydroxy-4-androstene-3,17-dione is also widely used in reproductive health supplements. It may improve reproductive health in both men and women by promoting testosterone synthesis, reducing testosterone metabolism, and improving other reproductive functions. For example, 9-hydroxy-4-androstene-3,17-dione is thought to increase sperm count and quality, improve erectile function, and reduce menstrual disorders, among other problems.
6. Food additives:
9-hydroxy-4-androstene-3,17-dione can also be used as a food additive. Because of its various biological activities and nutritional effects, including promoting protein synthesis, maintaining bone density, regulating lipid metabolism, etc., it is often added to sports nutrition, health food, beverages, etc. to help people improve their physical fitness and maintain healthy.
7. Other purposes:
In addition to the above uses, 9-hydroxy-4-androstene-3,17-dione also has some other potential applications. For example, it is considered that it may be used to treat chronic diseases such as arthritis, diabetes, and cardiovascular disease; it can also be used as an anti-stress agent, antioxidant, and immunomodulator, etc., to enhance the body's immunity and coping ability.
8. Anti-inflammatory and anti-allergic: 9-hydroxy-4-androstene-3,17-dione may have anti-inflammatory and anti-allergic effects. It modulates immune responses and cell signaling pathways, reducing inflammatory responses and allergic symptoms. Therefore, it has the potential to be used in the treatment of inflammatory and allergy-related diseases such as asthma, allergic rhinitis, and skin inflammation.
9. Anti-tumor: Some studies have shown that 9-hydroxy-4-androstene-3,17-dione may have an inhibitory effect on certain tumors. It can interfere with the proliferation and invasion ability of tumor cells, induce apoptosis, and inhibit tumor angiogenesis. Although the relevant research is still in its infancy, this compound is expected to become a new type of anti-tumor drug or adjuvant therapy drug.
10. Cardiovascular protection: 9-hydroxy-4-androstene-3,17-dione may have cardiovascular protection. It can regulate blood lipid metabolism, improve the process of arteriosclerosis, and reduce the risk of cardiovascular diseases. Further research can explore its potential application in cardiovascular disease prevention and treatment.
It should be noted that although 9-hydroxy-4-androstene-3,17-dione has a wide range of biological activities and potential application value, its safety and side effects still need further research and evaluation. When using or developing related products, they must be used strictly in accordance with relevant laws and regulations, and follow the advice of doctors or professionals.